Cognitive benefits of sleep and their loss due to sleep deprivation

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NEUROLOGY 2005;64:E25-E27
© 2005 American Academy of Neurology
Resident and Fellow Page

Cognitive benefits of sleep and their loss due to sleep deprivation
Jeffrey M. Ellenbogen, MD

From the Department of Neurology, University of Pennsylvania, Philadelphia.

Address correspondence and reprint requests to Dr Ellenbogen, Department of Neurology, University of Pennsylvania, 3 West Gates Bldg., 3400 Spruce Street, Philadelphia, PA 19104-4283; e-mail: jeffreye@mail.med.upenn.edu

When Nobel laureate Otto Loewi discovered the chemical basis of neurotransmission in 1921, he attributed his experimental design to an insight he made during sleep.1 In recent years, scientific discoveries have begun to empirically validate the hypothetical role of sleep in cognitive processes such as insight formation and memory consolidation. Yet these new and important scientific findings—that sleep benefits cognition—have gained little attention in the debates over regulating resident work hours.

In this article, I aim to achieve three goals: First, I will show that sleep deprivation causes two independent negative consequences to cognition: a detriment and a loss of benefit; I will explain this distinction. Second, I will briefly review evidence supporting sleep’s benefits for cognition. Finally, I will argue that these benefits of sleep for cognition provide novel reasons why depriving residents of sleep is inconsistent with our ethical standards and educational goals for medical training. In this final section, I will also argue against the assertion that residents should use performance-enhancing medications to overcome the effects of sleep deprivation.

Sleep loss: Distinguishing detriments from loss of benefits

Sleep loss causes profound impairments in cognitive and behavioral performance. For example, in a prospective, randomized study looking at the effects of sleep deprivation in residency training, interns working a "traditional schedule" made 36% more serious medical errors compared with interns under an "intervention schedule" that included more sleep.2 Another study demonstrated that traditional-schedule interns had more than twice the rate of attentional failures when compared with the intervention-schedule interns.3 Taken together, these studies demonstrate that sleep-deprived house staff make a significant amount of serious medial errors, largely the consequence of attentional failures from sleepiness. These excellent studies provide empirical evidence for the cognitive detriments of sleep loss.

Recently published studies (see below) looking at the benefits of sleep take a different, but complementary, approach. They seek to understand the benefits of sleep, rather then the detriments of sleep loss. This is a subtle but important distinction. Instead of studying the negative consequences of sleep loss, these studies seek to understand the positive gains produced by sleep. If these cognitive benefits of sleep exist, then missing sleep would hypothetically deprive a person of them.

Were one not aware of this loss of benefit, poor performance during cognitive testing on the morning following a night of missed sleep would be entirely attributed to the detriments from sleep loss. The missed benefits would go unnoticed. By analogy, if you do not deposit money in a bank, and it is subsequently stolen, your losses may be calculated as the amount of money stolen. However, the real amount of money lost is the quantity stolen, plus that which would have been added had it been in the bank earning interest prior to being stolen.

Evidence supporting cognitive benefits of sleep

Evidence for a beneficial role of sleep in cognition is rapidly emerging in the cognitive and neuroscience literature.4–8 These studies isolate sleep’s benefit by comparing a sleep period with a non-sleep-deprived wake period. The paradigm is as simple as it is insightful: control participants train on a cognitive task in the morning and are tested 12 hours later; they are compared with a group that trains at night, sleeps, and is tested 12 hours later.

Walker et al.4 performed a study that illustrates the paradigm (figure). There are two groups of participants: the wake-control group and the sleep-experimental group. The wake-control participants engage in a motor-learning task at 10 am, where they practice a particular set of sequences on a keyboard. The last few trials of the training session are taken as a marker of their best performance (speed and accuracy). Next, they are tested on the same task at 10 pm (12 hours later). The sleep-experimental participants learn the task at 10 pm, sleep overnight, and are tested at 10 am on the following morning. The sleep group shows significantly greater improvement in performance, from training to testing, when compared with the wake controls. This experimental paradigm has been successfully employed to show the benefit of sleep for several forms of neural processing, including insight formation,5 novel-language perception,6 visual discrimination,7 and motor skills.8

There is not universal agreement that sleep benefits cognition.9 However, many recently published studies employ improvements in methodology, including avoiding the use of sleep deprivation, and they no longer focus exclusively on REM sleep. These studies provide strong evidence for sleep-dependent cognitive processing.

In addition to the behavioral data, there is also a biologically plausible mechanism for sleep benefiting memory: the hippocampal-neocortical dialogue. Simplified, this hypothetical model asserts that, in wakefulness, information is encoded in the hippocampus. During the subsequent slow wave sleep, the encoded memory trace is replayed by the hippocampus; the movement of information between the neocortex and hippocampus then repeats over each sleep cycle. This reiterative process is thought to facilitate consolidation of memory traces. Evidence for the hippocampal–neocortical dialogue already exists in animals,10 and translational research looking at declarative (hippocampal-dependent) memory in humans is currently under way.

Performance-enhancing medication for residents

Some physicians advocate that sleep-deprived residents be required to take medication such as modafinil or more traditional stimulants (including caffeine) to overcome the cognitive and behavioral detriments resulting from sleep loss. There are several serious problems with this proposal: First, no medication is free of side effects. Compelling house staff to consume medication, in order to adequately perform their job, exposes them to these agents’ potentially serious risks (known or unknown) or merely unpleasant side effects or both. Second, there are serious ethical concerns raised by employing medications for "performance enhancement,"11 and the medical community is not exempt from such considerations.

Finally (and most relevant for this article), taking medication will—in principle—not recover the benefit sleep has to offer cognition. Even if we hypothetically could safely and completely restore sleep-deprived arousal and attention impairments by administering medication, a memory trace that was not consolidated during a night of lost sleep could not be recovered thereafter.

Conclusion

If the demands of residency training result in sleep-depriving house staff, this will impair residents’ cognitive processing for two independent reasons: detriments and loss of benefits. The detriments resulting from sleep loss include impaired cognitive and behavioral performance, partly from diminished attention and arousal. The loss of benefits due to the lack of sleep includes missing sleep-dependent cognitive processing such as memory consolidation and insight formation.

Detriments due to sleep loss compromise the health and well-being of residents (including placing them at risk for motor vehicle accidents)12 and negatively impact the outcome of the patients they are trying so hard to serve.2,3 This has recently been demonstrated by a series of rigorous studies and should impact our evidenced-based medical practices and policies.

Sleep deprivation also results in the loss of sleep’s benefits for cognitive processes such as memory and insight formation: the building blocks of learning, creativity, and scientific discovery. These losses are also ethically problematic, incompatible with our health-providing goals, and inconsistent with the educational aspirations of residency training.

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